IL-4-590C/T基因多态性与儿童支气管哮喘关系的Meta分析

摘要

目的 探讨白细胞介索4(IL-4)基因-590C/T(rs2243250)多态性与儿童支气管哮喘(简称哮喘)发病风险的相关性.方法 计算机检索CNKI期刊全文数据库、万方医学期刊数据库、维普医药信息资源系统、Pubmed、百度学术、谷歌学术有关IL-4基因-590C/T多态性与儿童哮喘发病风险的病例-对照研究,检索时限均为从建库至2016年1月.采用RevMan 5.2软件和Sta-ta12.0软件进行Meta分析,计算合并OR值以及95％可信区间(CI).结果 最终纳入7个病例对照研究,共计哮喘患者1 167例为病例组和1 101例健康者为对照组.Meta分析结果显示,5种遗传基因型CT+ CC和TT,CC和CT+ TT,CC和TT,CC和CT,C和T都可增加儿童支气管哮喘发病风险,5种基因型的OR(95％CI)分别为0.7(0.57～0.85),0.56(0.43～0.72),0.46(0.33～0.64),0.64(0.48～0.85),0.45(0.27～0.77);人种亚组分析结果显示,在亚洲人群中基因型CC和CT+ TT,CC和TT,CT和TT,C和T与儿童支气管哮喘发病风险存在相关性,OR(95％CI)分别为0.50(0.35～0.72),0.50(0.27～0.95),0.61(0.41～0.92),0.47(0.23～0.95),P值分别为0.01、0.04、0.02、0.03,在非亚洲人群中基因型CC和CT+ TT,CC和TT,CC和CT与儿童支气管哮喘发病相关OR(95％CI)分别为0.63(0.44～0.90),0.49(0.25～0.96),0.67(0.45～0.98),P值分别为0.01、0.04、0.04.结论 IL-4基因-590C/T多态性与儿童支气管哮喘易感性相关.%Objective To investigate the relationship between polymorphism of IL-4-590C/T and susceptibility of asthma.Methods The case-control articles reporting the relationship between IL-4-590C/T polymorphism and susceptibility of asthma were collected by China National Knowledge Infrastructure,WanFang data,VIP citation databases,Pubmed,Baidu Scholar,time limits are retrieved from the building a database to January 2016.The Meta-analysis software RevMan5.0 and Stata 12.0 was applied for heterogeneity test and pooled OR calculation.Results Seven case-control studies were selected,including 1 167 cases in the asthma group and 1 101 cases in the control group.Meta-analysis showed that both-590C/T polymorphisms genotypes were significantly associated with asthma,five kinds of senotypes OR(95％ CI) were CT+CC vs.TT[0.7 (0.57-0.85)],CC vs.CT+ TT [0.56(0.43-0.72)],CC vs.TT[0.46(0.33-0.64)],CC vs.CT[0.64(0.48-0.85)],C vs.T[0.45(0.27-0.77)].From subgroup analysis,genotype CC vs.CT+TT[0.50(0.35-0.72)],CC vs.TT[0.50(0.27-0.95)],CT vs.TT[0.61(0.41-0.92)],C vs.T[0.47 (0.23-0.95)] with risk correlated in Asian children asthma(P value is 0.01,0.04,0.02,0.03).Genotype CC vs.CT+TT[0.63(0.44-0.90)],CC vs.TT[0.49(0.25-0.96)],CC vs.CT[0.67(0.45-0.98)] also indicated a significant correlation between-590C/T polymorphisms of IL-4 and asthma in non-Asian children(P value is 0.01,0.04,0.04).Conclusion Current evidence suggests that the-590C/T polymorphism of IL-4 gene is associated with children asthma.