2型糖尿病患者抑郁情绪对血糖控制的影响

摘要

Objective To investigate the influence of depression on glycemic control in the patients with type 2 diabetes mellitus(T2DM).Methods The Zung self-rating depression scale(SDS) was used to assess depression.A total of 276 cases of T2DM were divided into the group A(SDS standard score ≥53 points) and B(SDS standard score ＜53points).The levels of HbA1c,FPG,HOMA-IR,etc.were compared between the two groups,and the influencing factors of glycemic control in T2DM patients were analyzed.Results In the patients with T2DM,the SDS standard score was correlated with HbA1c(r=0.26,P＜0.05).The multivariate regression analysis showed that the SDS standard score was still correlated with HbA1c (β =0.30,t =5.1,P＜ 0.05).The HbA1c level in the group A was higher than that in the group B(t=3.685,P＜0.05);after correcting the factors of sex,age and education,the HbA1c level in the group A was still higher than that in the group B(F=47.8,P＜0.05).Conclusion The depression mood is adverse to glycemic control in T2DM patients.%目的 探讨2型糖尿病(T2DM)患者抑郁情绪对血糖控制的影响.方法 应用Zung抑郁自评量表(SDS)评估抑郁情况,276例T2DM患者分为SDS≥53分(A组)、SDS＜53分(B组).比较两组糖化血红蛋白(HbA1c)、空腹血糖(FPG)及胰岛素抵抗指数(HOMA-IR)等,分析T2DM患者血糖控制的影响因素.结果 T2DM患者SDS标准分与HbA1c呈正相关(r=0.26,P＜0.05).多元回归分析显示T2DM患者SDS标准分与HbA1c仍相关(β=0.30,t=5.1,P＜0.05).A组HbA1c水平高于B组(t=3.685,P＜0.05);当校正性别、年龄、受教育程度等因素后,A组HbA1c仍高于B组(F=47.8,P＜0.05).结论 抑郁情绪不利于T2DM患者血糖控制.