精神分裂症既往生活节奏与事件相关电位P300研究

摘要

Objective To explore the relationship of lifestyle stress, clinical symptom and event-related potential P300 in Schizophrenic patients. Methods Event-related potential P300 and the degree of lifestyle stress were measured in 203 schizophrenic patients and 192 normal controls. The clinical symptoms were measured by the Positive and Negative Syndrome Scale. Results There were significantly difference between schizophrenic patients and normal controls in lifestyle stress. Compared with normal controls, Group with tense living tempo schizophrenic patients with lifestyle stress had lower P300-N1 amplitude and score of dysboulia but a higher PANSS score of depression than did those without lifestyle stress. Conclusion Lifestyle stress in the past may be one of the factors that induce brain dysfunction in schizophrenic patients.%目的 探讨精神分裂症患者既往生活节奏与临床症状、事件相关电位P300的关系.方法 收集203例精神分裂症患者和192名健康人既往生活节奏与P300资料,用阳性和阴性症状量表(PANSS)评定患者的临床症状.结果 精神分裂症组与健康对照组的既往生活紧张程度差异有统计学意义(P＜0.05).生活很紧张组的精神分裂症患者较生活不紧张组的P300-N1波幅降低,PANSS抑郁分增高,意志障碍分下降.结论 既往生活节奏紧张可能是精神分裂症脑功能损害的因素之一.