低剂量18F-氟代脱氧葡萄糖PET/CT在体检中发现恶性肿瘤的意义

摘要

Objective To assess the significance of low-dose fluorodeoxyglucose (18F-FDG) PET/CT for screening of malignant tumors during physical examination.Methods We reviewed the clinical profiles of 469 individuals who received health check-up with 18F-FDG PET/CT.This entailed comparison with the findings during follow-up visits between September 2010 and October 2012.Results Thirteen patients with malignant tumors were identified by 18F-FDG PET/CT,of whom 8 had pulmonary carcinoma,and a single case with thyroid cancer,cardiac carcinoma,ovarian cancer,ascending colon cancer and renal cancer,respectively.Except for 2 cases with bronchoalveolar carcinoma,1 with neuroendocrine carcinoma and 1 with renal carcinoma judged to be false negative,all miscellaneous cases yielded an increased metabolism of 18F-FDG.Conclusion Low-dose PET/CT is safe and significant for screening of malignancy in physical examination.%目的 评价低剂量18F-氟代脱氧葡萄糖(18F-FDG) PET/CT在体检中发现恶性肿瘤的意义.方法 回顾分析2010年9月至2012年10月469例18F-FDG PET/CT健康体检者的资料,并对照随访结果.结果 18FFDG PET/CT显像共发现恶性肿瘤13例,其中肺癌8例,甲状腺癌、贲门癌、卵巢癌、升结肠癌、肾细胞癌各1例.2例支气管肺泡癌、1例神经内分泌癌及1例肾细胞癌为假阴性,其余18F-FDG代谢均增高.结论 低剂量18F-FDG PET/CT在体检中进行肿瘤筛查是安全的,具有重要意义.