Objective To investigate the expression of metadherin (MTDH) and p53 gene in esophageal squa-mous cell carcinoma (ESCC) and its relationship with clinicopathological features. Methods Immunohistochemistry was used to determine the expression levels of MTDH and P53 protein in the tissues of 78 cases of ESCC, and 25 cases of intraepithelial neoplasia and normal esophageal mucosa. Results The positive expression rate of MTDH in the tissues of normal esophageal mucosa, high grade intraepithelial neoplasia and ESCC was 8%, 64% and 72%, re-spectively (P0.05). The protein expression of MTDH and P53 were not related to age, gender and invasion depth of patients. Conclusion The overexpression of MTDH and P53 protein is closely related to the occurrence and development of ESCC, which play an important role in the invasion and metastasis of esophageal cancer, and can be used as an important indicator for the prognosis of esophageal cancer.%目的：研究异黏蛋白（MTDH）和p53基因在食管鳞状细胞癌中的表达及其与临床病理特点之间的关系。方法采用免疫组织化学方法检测78例食管鳞癌患者的食管鳞状细胞癌组织、25例上皮内瘤变和25例正常食管黏膜组织中MTDH和P53蛋白的表达情况。结果 MTDH在正常食管黏膜组织、高级别上皮内瘤变、食管鳞状细胞癌组织中的阳性表达率分别为8％、64％和72％（P＜0.01），MTDH与食管鳞状细胞癌的分化程度、淋巴结转移差异有统计学意义（P＜0.05）。P53蛋白在正常食管黏膜组织、上皮内瘤变、食管鳞状细胞癌组织中的表达亦逐渐升高，分别为4％、48％、58％（P＜0.01）。 P53蛋白与食管鳞状细胞癌组织分化程度差异有统计学意义（P＜0.05），有淋巴结转移食管癌患者P53蛋白阳性率高于无淋巴结转移者（65％、47％），但2组间比较差异无统计学意义（P＞0.05）。 MTDH和P53蛋白的表达与患者年龄、性别、浸润深度无关。结论 MTDH和P53蛋白的过度表达与食管鳞状细胞癌的发生、发展密切相关，在食管癌的侵袭和转移过程中发挥了重要作用，可作为预测食管癌预后的重要指标。
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