目的 分析急性白血病患者初次诱导化疗期间侵袭性真菌感染临床特点、危险因素.方法 回顾性分析2015年1月至12月山西医科大学第二医院血液科病房收治的200例急性白血病患者真菌感染临床特点.结果 200例急性白血病患者诱导化疗期间确诊/临床诊断侵袭性真菌病率为25%(50/200),共检出病原菌47株,念珠菌占89%(42/47),居前三位的感染部位是肺部、血流、胃肠道,多因素Logistic回归分析发现年龄≥60岁、中性粒细胞缺乏是真菌感染危险因素(P<0.05).结论 急性白血病患者初次诱导化疗期间真菌感染率高,肺部为最常见感染部位,且以念珠菌居多,常发生于老年患者、中性粒细胞缺乏期.%Objective To investigate the clinical characteristics and risk factors of invasive fungal infection in patients with acute leukemia during induction chemotherapy. Methods The clinical characteristics of fungal infec-tion in 200 patients with acute leukemia, who were hospitalized in the Department of Hematology, the Second Hospital of Shanxi Medical University between January 2015 and December 2015, were retrospectively analyzed. Results The prevalence rate of invasive fungal infection in the 200 patients with acute leukemia during induction chemotherapy was 25% (50/200). Forty-seven pathogens were detected, and Candida accounted for 89% (42/47). The first three in-fection sites were lung, bloodstream, and gastrointestinal tract. Multivariate logistic regression analysis found that age≥60 years old and neutropenia were risk factors for invasive fungal infection ( P<0.05). Conclusion The prevalence rate of invasive fungal infection in patients with acute leukemia during induction chemotherapy is high. Lung is the most common infection site, with the majority of Candida. The invasive fungal infection occurs frequently in senile patients with neutropenia.
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