Tramacol- induced Physical Dependence and Its Effects on Behavioral Sensitization to Mthamphetamine in Mice

摘要

AIM:Tramado is a centrally acting,synthetic analgesic with opioid agonist properties and effects on monoaminergie transmission,It is the unique non-controlled analgesic for the treatment of moderately severe acute or chronic pain.In recent years,however,some epidmiological data indicate that tramadol possess relatively high poly-drug abuse potential.