IKKβ结构与功能及其抑制剂研究进展

摘要

The inhibitor kappa B kinase β ( IKKβ ) is the crucial catalytic subunit of the IKK complex in the course of the nuclear transcription factor kappa B ( NF-kB ) activation via classical ( or canonical) pathway. Not IKKβ is only regulated by various upstream kinases, but also it regulates the expression of multiple target genes related to many diseases. Especially, it plays a cru-cial role in the development of inflammatory response and cancer , providing a molecular link between inflammation and cancer. To sum up, this article reviews the structure, function of IKKβ, as well as the development of inhibitors in these years.%IκB激酶β(inhibitor kappa B kinase β,IKKβ)是IKK复合物中介导核转录因子(nuclear transcription factor kappa B,NF-κB)活化经典途径的关键亚基.IKKβ活性受到上游激酶调节的同时,也参与调控与多种疾病相关的靶基因,尤其在肿瘤与炎症的发生发展过程中发挥重要作用,在炎症与肿瘤之间搭建了一座桥梁.该文就IKKβ在肿瘤发生发展过程中作用及其抑制剂的研究进展予以综述.