TNIK IKK TBK1 COMPOUNDS AS TNIK IKK AND TBK1 INHIBITORS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

摘要

The present invention as TNIK (Traf2- and NCK-interacting kinase), IKKε (I-kappa-B kinase epsilon) and TBK1 (TANK-binding kinase 1) inhibitor, relates to a compound of formula 1, the compounds according to the invention are TNIK , it acts as an effective inhibitor for IKKε and TBK1, colon cancer, breast cancer, central nervous system cancer, colon cancer, non-small cell lung cancer, renal cancer, prostate cancer, ovarian cancer, uterine cancer, stomach cancer, liver cancer, skin cancer, lung cancer, brain cancer, bladder cancer, to esophageal cancer, pancreatic cancer, thyroid cancer, skin cancer, squamous cell carcinoma, osteosarcoma, as well as cancer cells or B- for various cancers including the T- cell lymphoma, acute or chronic leukemia, and multiple myeloma is useful as a therapeutic agent for chronic inflammation It can be used.