瞬时感受器电位通道在肿瘤增殖与迁移中的作用

摘要

瞬时感受器电位( transient receptor potential, TRP)超家族成员是位于细胞膜上的一类广泛分布的非选择性阳离子通道,激活TRP通道多可引起胞质游离Ca2+浓度升高,调节细胞增殖、迁移和转移。目前研究表明, TRP通道与多种肿瘤的发生和发展密切相关。该文对目前 TRPC、TRPV和TRPM通道在肿瘤增殖与迁移中的作用进行综述。%The transient receptor potential( TRP) subfamilies be-long to the non-selective cation channels located at cell mem-branes. Calcium across the plasma membrane into the cell via most TRP channels may result in localized Ca2+ signals that con-tribute to cell proliferation, migration and metastasis. In recent years, many studies have focused on the role of TRP in cancer. This review intends to gather the latest progress concerning TRP channels on proliferation and migration of cancer.