Gastric cancer has a high incidence and accounts for a notable proportion of global cancer mortality.The pathogenesis of gastric cancer is complex involving multiple genetic and epige-netic alterations factors.In recent years,studies have also dem-onstrated the aberrant regulation of miRNAs in a variety of tumor pathological processes including the gastric cancer through af-fecting cell proliferation,differentiation and apoptosis.miRNA also plays important roles in gastric cancer growing,invasion, metastasis,and drug resistance of gastric cancers,which might become new biomarkers and potential therapeutic targets in the future.This paper summarizes several important miRNAs in-volved in gastric cancer and also discusses their function.%胃癌始终具有高发病率及死亡率，其发病机制复杂、多元化，涉及众多遗传学和表观遗传学的改变。近年来，越来越多的证据表明，微小RNA（microRNA，miRNA）可以影响细胞的增殖、分化、凋亡，参与到包括胃癌在内的多种肿瘤病理过程中。miRNA不仅与胃癌的发生、发展、浸润、转移有关，而且与胃癌细胞抗药性存在密切联系；此外，miRNA极有可能成为胃癌标志物，提供新的治疗目标和治疗手段。该文主要介绍miRNA结构和生物学功能，以及其在胃癌中发挥的作用。
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