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MICRORNA BIOMARKER FOR THE DIAGNOSIS OF GASTRIC CANCER

机译:微小RNA生物标志物诊断胃癌

摘要

Disclosed are methods of determining the likelihood of a subject having or developing a gastric cancer. The methods comprise measuring the expression level of at least one miRNA having at least 90% sequence identity with an miRNA as described herein in a non-cellular biofluid sample obtained from the subject, wherein differential expression of miRNA expression in the sample obtained from the subject, as compared to a control, may be indicative of the subject having gastric cancer and wherein the miRNA may be either an miRNA listed as “up-regulated” or an miRNA listed as “down-regulated”. Also disclosed is a method of determining the likelihood of a subject having or developing a stage of a gastric cancer.
机译:公开了确定受试者患有或发展为胃癌的可能性的方法。该方法包括在获自受试者的非细胞生物流体样品中测量与本文所述的miRNA具有至少90%序列同一性的至少一种miRNA的表达水平,其中获自受试者的样品中miRNA表达的差异表达。与对照相比,β-RNA可以指示患有胃癌的受试者,并且其中miRNA可以是被列为“上调”的miRNA或被列为“下调”的miRNA。还公开了一种确定受试者患有或发展为胃癌阶段的可能性的方法。

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