TXNIP介导的氧化应激在疾病中的作用机制

摘要

硫氧还蛋白相互作用蛋白(TXNIP)通过与硫氧还蛋白(Trx)的结合而抑制Trx的抗氧化作用,促进了活性氧簇(ROS)的产生与积聚,诱发内质网应激与线粒体应激,最终可诱导炎症或细胞凋亡.TXNIP所介导的氧化应激在糖尿病及其并发症(糖尿病肾病、糖尿病视网膜病变等)、动脉粥样硬化、缺血/再灌注损伤、癌症(肝细胞癌、膀胱癌、乳腺癌、白血病)等疾病的发生、发展过程中起着重要的调控作用.该文就TXNIP介导的氧化应激在相关疾病中的作用机制及研究进展进行综述.%Thioredoxin-interacting protein ( TXNIP) suppresses the antioxidative function of thioredoxin ( Trx ) by combining with thioredoxin ( Trx).Therefore, it promotes the generation and accumulation of reactive oxygen species ( ROS ) , inducing endoplasmic reticulum stress and mitochondrial stress , which leads to cellular inflammation or cellular apoptosis ultimately . TXNIP-mediated oxidative stress plays a crucial role in control-ling the generation and development of some diseases , such as diabetes and its complications ( diabetic nephropathy diabetic retinopathy etc .) , atherosclerosis ischemia/reperfusion injury , cancers ( hepatocellular carcinoma , carcinoma of urinary blad-der, mammary cancer , leukemia ) etc.Here, we try to review the action and mechanism of oxidative stress mediated by TXNIP in the diseases and the progress in research .