Oxidative Stress and Cell-mediated Immunity in Gestational Diabetes Mellitus

摘要

The association between oxidative stress and lymphocyte sub-population was evaluated in peripheral blood of women with gestational diabetes mellitus (GDM), Type II diabetes and compared with healthy controls. The results revealed expansion of CD4+CD25+ (P<0.05), CD4+CD45RO+ (P<0.05) and CD4+CD29+ (P<0.01), but lower percentages of CD4+CD45RA+ (P<0,0.5) in the GDM cohorts but not in Type II diabetes compared with healthy pregnant women. Total antioxidant activity was higher among healthy pregnant women compared with non-pregnant women (p<0.05) which was not observed in the diabetic cohorts. Both Type II diabetic groups showed higher levels of malondialdehyde (MDA) relative to non pregnant cohort; conversely, SOD was significantly decreased (p<0.05). Women with GDM and those with Type II diabetes have increased oxidative stress and subsequent lymphocyte activation.