Protective effect of capsaicin against methyl methanesulphonate induced toxicity in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg9

摘要

Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is the main component in hot peppers,including red chili peppers,alapenos,and habanero,belonging to the genus Capsicum.Capsaicin is a potent antioxidant that interferes with free radical activities.In (t)he present study,the possible protective effect of capsaicin was studied against methyl methanesulphonate (MMS) induced toxicity in (t)hird instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg9.The third instar was allowed to feed on the diet having differ(e)nt doses of capsaicin and MMS separately and in combination.The results suggested that the exposure of third instar larvae to the diet (n)aving MMS alone showed significant hsp70 expression as well as tissue DNA and oxidative damage,whereas the larvae feed on the diet (h)aving MMS and capsaicin showed a decrease in the toxic effects for 48-h of exposure.In conclusion,capsaicin showed a dose-dependent (d)ecrease in the toxic effects induced by MMS in the third instar larvae of transgenic Drosophila melanogaster.