肿节风总黄酮对阿糖胞苷诱发小鼠血小板减少症模型的影响

摘要

Objective Using cytarabine thrombocytopenia after chemotherapy mice model was established, the effects of total flavones from Herba Sarcandrae on thrombocytopenia after chemotherapy treatment effect and mechanism of mouse model. Methods Mice were injected AraC causes thrombocytopenia model, and through the Sarcandra glabra and its separated parts of theintragastric administration, then the total flavonoids of Herba Sarcandrae on murine peripheral blood were observed. Results Miceafter injection of cytarabine after modeling, the model group PLTwere significantly lower than those in normal control group, with statistical significance difference ( P<0.05) ; Total Flavonoids in Herba Sarcandrae dose group, positive drug prednisolone group PLT was higher than that in the model group, the difference of data with statistical significance ( P<0.05) ; MP group WBC positive drug strongwere significantly lower than those in normal control group, with statistical significance difference ( P<0.05) ; while the MPV, RBC, HGB compared with the control group, the data have no significant difference ( P>0.05) , cytarabine had no influence on its. Conclusion Cytarabine can cause tumor bearing rat thrombocytopenia model, the total flavonoids of Herba Sarcandrae can significantly promoted effect on platelet play.%目的：利用阿糖胞苷建立化疗后血小板减少小鼠模型，研究肿节风总黄酮对化疗后血小板减少小鼠模型的治疗效果及机制。方法小鼠注射阿糖胞苷造成血小板减少模型，并通过对肿节风及其各分离部位进行灌胃用药，就肿节风总黄酮对小鼠外周血象变化进行观察。结果小鼠经注射阿糖胞苷造模后，模型组血小板数显著低于正常对照组，数据差异具有统计学意义（P<0.05）；肿节风总黄酮中剂量组、阳性药强的松龙组PLT显著高于模型组，数据差异具有统计学意义（P<0.05）；阳性药强的松龙组WBC显著低于正常对照组，数据差异具有统计学意义（P<0.05）；而MPV、 RBC、 HGB与正常对照组相比，数据差异无显著性（P>0.05），阿糖胞苷对其无影响。结论阿糖胞苷能够有效造成小鼠血小板减少模型，肿节风总黄酮能够明显对血小板起到提升作用。