双氢青蒿素与甲氟喹联用治疗恶性疟疾的疗效观察

摘要

Objective　To evaluate the clinical efficacy of dihydroartemisinin—mefloquine on acute uncomplicated falciparum malaria. rnMethods　Fifty-four patients with symptomatic falciparum malaria were allocated to receive oral dihydroartemisinin at a single dose of 120?mg on day 1, followed by mefloquine, 750?mg and 500?mg on days 2 and 3, respectively. Follow-up was performed on days 1,2,3,4,7,14,21, and 28. rnResults　All patients had a rapid initial response to treatment. The parasite clearance time (PCT) after treatment was 30.7±3.6 hours. The fever subsidence time (FST) after treatment was 21.2±2.8 hours. Two patients had a recrudescence 21 and 25 days respectively after the disappearance of parasitemia, hence the recrudescence rate was 3.7% and the cure rate was 96.3%. No serious adverse effects were observed, only mild and transient nausea, vomiting and loss of appetite. rnConclusion　A combination of dihydroartemisinin and mefloquine is effective in the treatment of acute uncomplicated falciparum malaria.%目的观察双氢青蒿素与甲氟喹联用治疗急性无并发症恶性疟疾的临床疗效。rn方法以首日单剂双氢青蒿素120mg顿服，次日及第三日甲氟喹750mg及500mg顿服的3日疗法，治疗无并发症的恶性疟54例，并于治疗后1、2、3、4、7、14、21和28天进行了随访。rn结果 54例患者经治疗后全部临床治愈，平均疟原虫转阴时间为30.7±3.6小时。平均退热时间为21.2±2.8小时，54例中2例在疟原虫血症消失后第21、25天复燃，复燃率3.7%；治愈率96.3%。除少数病人发生轻微及短暂的恶心呕吐、纳差外，余未发现严重不良反应。rn结论双氢青蒿素与甲氟喹联用 3日疗法治疗无并发症恶性疟疾具有良好疗效。