Objective To study the influence of airflow movement driven mainly by two patterns of BSL laboratory ventilation (i.e. top -supply & top -exhaust ventilation and top -supply & down -exhaust ventilation) and location of contaminant source on distribution of aerosol particle concentration. Methods The track of aerosol particles was simulated by using discrete trajectory model, and coupling was made with a standard turbulence model of , which was a model of simulating airflow movement. Results Under the conditions when air output, pressure and emission power were remained unchanged in main room, the ventilation was a factor for distribution of aerosol particles, moreover, the location of contaminant source was also an important factor for indoor distribution of aerosol particles. Conclusion A comparison among six options indicates that the respiratory room has minimum concentration and better contaminant removal efficiency as a whole, if the contaminant source with top-supply & top-exhaust ventilation is located at the position 1; respiratory room has maximum concentration and worst contaminant removal efficiency as a whole, if the contaminantrnsource with top-supply & down-exhaust ventilation is located at position 3.%目的:对BSL-3主实验室上送上排、上送下排2种通风方式的气流运动以及污染源位置对气溶胶颗粒浓度分布影响进行数值研究.方法:利用离散轨道模型模拟气溶胶颗粒的轨迹,并与模拟气流运动的标准湍流模型相耦合.结果:在主实验室送风量、压力以及污染源发射强度不变的情况下,不仅通风方式是影响气溶胶颗粒分布的因素,污染源发生位置也是影响室内颗粒浓度分布的重要因素.结论:对比6个方案,上送上排污染源在位置1时呼吸区有最小的浓度和更好的整体排污效率,上送下排污染源在位置3时呼吸区有最大的浓度和最差的整体排污效率.
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