Objective To abstract practice-oriented knowledge from a cohort of real clinical pathways and to represent this knowledge as a clinical pathway ontology. Methods Engineering methodology was adopted to construct clinical pathway knowledge base, which included(l)knowledge source identification and classification of clinical pathways according to variations in setting, stage of care, patient type, outcome and specialty;(2)iterative knowledge abstraction using grounded theory; (3)ontology engineering as adapted from the Model -based Incremental Knowledge Engineering approach; and(4)ontology evaluation through encoding a sample of real clinical pathways. Results The clinical pathway ontology knowledge base was developed, which included 58 class diseases, and was applied in real clinical setting. Conclusion Clinical pathway ontology knowledge base has significant function in the electronic application of clinical pathway, which will be a reference fordeveloping a new generation of electronic medical records.%目的:从一组实际运行的临床路径应用中提取面向实践的临床知识,实现临床路径本体知识库的规范表达.方法:采取工程化方法建立临床路径知识库,包括临床路径知识源标识与分类、知识抽象方法、本体工程方法和临床路径本体评价.结果:建立了58个病种临床路径本体知识库,并在实际应用中进行了验证.结论:临床路径本体知识库建设对临床路径电子化深度应用有重要意义,对新一代电子病历研发有参考借鉴作用.
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