链球菌毒力因子溶血素S的研究进展

摘要

链球菌溶血素S(Streptolysin S,SLS)是链球菌产生的重要毒力因子之一.化脓链球菌、海豚链球菌、咽峡炎链球菌等多种人和动物致病性链球菌均含有该毒力因子,化脓链球菌是人类主要的病原菌,其致病机制备受关注.SLS是一个由sagA-sagⅠ9个连续基因编码修饰的多肽性细胞溶素,具有帮助致病菌渗透上皮屏障、造成组织损伤、抵抗宿主免疫细胞吞噬、与其他毒力因子相互作用的功能;SLS可作为细胞群体感应的信号分子,参与调节其他毒力因子的表达.本文对SLS的结构和在致病过程中的生物学功能作一综述.%Streptolysin S (SLS),one of the important virulence factors of Streptococcus,exist in several kinds of human and animal pathogenic bacterial,including Streptococcus pyogenes,Strepstococcus iniae and Streptococcus anginosus.SLS is a peptide toxin encoded by nine consecutive genes (sagA-sagⅠ).The functions of SLS include contributing pathogenic bacterium to pass through epithelial barrier,causing tissue damage,resisting to phagocytic clearance of host immune cells and interacting with other virulence factors.In addition,SLS as a signaling molecule of cell quorum sensing is involved in regulating the expression with other virulence factors.This paper summarized the structures and the biological functions of SLS in Streptococcus infection.