Objective To explore the influence of different therapy methods on vaginal internal environment of patients with BV and VVC . Methods Randomized control study was carned out on 264 VVC patients and 234 BV patients. Both of two kinds of patients were randomly divided into four groups : medicine therapy group , medicine combined with ozone therapy group , medicine combined with boracic acid (3% ) therapy group and pure ozone therapy group . Symptoms, signs and vaginal internal environment of them were observed throughout two times of follow-up. Results For BV patients, vaginal pH value had been recovered . The bacterial diversity was not significantly different among four groups before and after treatment (all P > 0. 05) , and the percentage of G+b(L) as the dominant bacteria had been gradually increased in medicine combined with ozone therapy group and pure ozone therapy group (χ2=40. 364, P < 0. 01 ). For VVC patients, vaginal pH value was not significantly different among four groups before and after treatment (all P > 0. 05 ). The bacterial diversity was significantly different in pure ozone therapy group (χ2= 9. 500, P < 0. 05 ) , and the percent of G bacillus ( long) as the dominant bacteria had been gradually increased (χ2= 14. 812, P < 0. 01). Conclusion For BV and VVC patients , ozone therapy cannot damage vaginal internal environment , and it is not significantly different from other therapy methods .%目的 探讨不同治疗方法 对细菌性阴道病和外阴阴道念珠菌病患者阴道内环境的影响.方法 采用随机对照研究方法 将264名外阴阴道念珠菌病患者及234名细菌性阴道病患者随机分为4组,分别是单纯用药组、药物配伍臭氧阴道冲洗组、药物配伍3%硼酸阴道冲洗组、单纯臭氧阴道冲洗组.对患者进行两次随访,记录患者的症状和体征改善情况以及阴道微生态情况.结果 细菌性阴道病不同治疗组的患者经治疗后阴道pH值逐渐恢复到正常范围;不同治疗组治疗前后阴道菌群多样性比较差异均无统计学意义(均P>0.05);药物配伍臭氧阴道冲洗组和臭氧阴道冲洗组患者阴道优势菌为革兰氏阳性大杆菌(乳酸杆菌)的比率逐渐增加(χ2=40.364,P<0.01).外阴阴道念珠菌病不同治疗组患者治疗前后阴道pH值比较差异均无统计学意义(均P>0.05);臭氧阴道冲洗组治疗前后菌群多样性比较差异有统计学意义(χ2=9.500,P<0.05);各组阴道优势菌为革兰氏阳性大杆菌(乳酸杆菌)的比率逐渐增加(χ2=14.812,P<0.01).结论 对于细菌性阴道病和外阴阴道念珠菌病患者,臭氧阴道冲洗不会破坏患者阴道内的微生态,与常规其它治疗方法 比较没有明显差异.
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