pharmaceutical formulation composition to treat a vaginal infection, and methods to treat a vaginal infection, to stabilize a clindamycin formulation, to treat or prevent a recurrence of a vaginal infection in a patient and to treat vaginal conditions

摘要

"PHARMACEUTICAL FORMULATION COMPOSITION TO TREAT A VAGINAL INFECTION, AND METHODS TO TREAT A VAGINAL INFECTION TO STABILIZE A CLINDAMICINE FORMULATION TO TREAT OR PREVENT A RECURRENCE OF A VAGINAL INFECTION AND A VAGINAL TRADITION A pharmaceutical formulation for treating vaginal conditions in a human patient comprises: at least one active agent; a modified release dosage form that provides sustained release of anti-infectious agent under vaginal administration to the patient; and in which the formulation, when containing a total anti-infectious agent dose of about 25 µg to about 500 mg based on the active agent, will produce a plasma concentration versus time curve (ng / mL versus hours) having an area under the curve (AUC) less than about 600 ng / mL.h.