Objective To investigate the curative effect of Jingangteng combined with Qianjinpian on chronic pelvic inflammation and its influence on levels of serum cytokines interleukin-6 ( IL-6 ) and grain-megakaryocyte colony stimulating factor ( GM-CSF ) .Methods Totally 73 cases of chronic pelvic inflammation were randomly divided into control group ( n=35 ) and observation group ( n=38 ) .The control group used Qianjinpian treatment only, and the observation group was treated with Jingangteng combining Qianjinpian treatment. Two groups were compared in terms of clinical efficacy, body temperature recovery time, abdominal pain disappearance time, hospital stay, life quality after treatment, serum levels of IL-6 and GM-CSF before and after treatment, and the incidence of adverse reactions.Results The total effective rate of the control group was 74.29%, which was significantly lower than that of the observation group (92.11%) (χ2 =5.672,P<0.05).The temperature recovery time, abdominal pain disappearance time, and length of hospital stay were significantly shorter in the observation group than in the control group (t value was 5.193, 7.021 and 11.021, respectively, all P<0.05).SF-36 life quality rating scale showed that after treatment the scores of each dimension were significantly higher in the observation group ( t value ranged 3.453-6.764,P<0.05).After treatment the serum IL-6 and GM-CSF levels declined in two groups (t value was 13.458, 2.342, 14.234 and 2.565, respectively, all P<0.05), and those in the observation group were significantly lower than those in the control group (t value was 10.234 and 3.425, respectively, both P<0.05).In the control group the occurrence of adverse reactions after treatment was 17.14%, which was significantly higher than that in the observation group (10.53%) (χ2 =4.998,P<0.05).Conclusion Jingangteng combined with Qianjinpian has remarkable efficacy on chronic pelvic inflammation and can significantly reduce serum IL-6 and GM-CSF levels, so it should be promoted in clinical practice.%目的 探讨金刚藤联合妇科千金片对慢性盆腔炎的疗效及其对患者血清白介素-6(IL-6)和粒-巨核细胞集落刺激因子(GM-CSF)水平的影响. 方法 将73例慢性盆腔炎患者按照随机分组方法分为对照组(n=35)与观察组(n=38). 对照组仅采用妇科千金片进行治疗,观察组在此基础上联合金刚藤进行治疗. 比较两组的临床疗效、体温恢复时间、腹痛消失时间、住院时间、治疗后生活质量、治疗前后血清IL-6 和GM-CSF水平变化情况及不良反应发生率. 结果 对照组临床总有效率为74.29%,显著低于观察组(92.11%)(χ2 =5.672,P<0.05);观察组体温恢复时间、腹痛消失时间、住院时间均显著小于对照组(t值分别为5.193、7.021、11.021,均P<0.05);根据SF-36生活质量评分量表,观察组治疗后量表各维度评分均显著高于对照组(t=3.453~6.764,均P<0.05);两组治疗后血清IL-6和GM-CSF水平均显著低于治疗前(t值分别为13.458、2.342,14.234、2.565,均P<0.05),且观察组治疗后上述指标水平均显著低于对照组治疗后(t值分别为10.234、3.425,均P<0.05);对照组治疗后不良反应发生率为17.14%,显著高于观察组(10.53%)(χ2 =4.998,P<0.05). 结论 金刚藤联合妇科千金片对慢性盆腔炎的疗效显著,可显著降低血清IL-6及GM-CSF水平,可在临床上进行推广.
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