D-二聚体在儿童支原体肺炎肺不张中的临床意义探讨

摘要

Objective To discuss the clinical significane of D-dimer(D-D)in diagnosis of atelectasis induced by mycoplasma pneumonia(MP)in children.Methods The clinical data of 103 children with MP,who were admitted in hospital from January 2012 to December 2013,were retrospectively collected to analyze the relationship between D-D value and incidence of atelectasis after treatment.Results The cases were divided into three groups according to D-D level,group A(DD <0.25ug/mL,52 cases),group B(1.0ug/mL> DD>0.25ug/mL,20 cases)and group C(DD≥1.0ug/mL,31 cases).The total incidence of atelectasis in three groups was 10.7%(11/103),and the incidence of atelectasis was 0%(0/52),15%(3/20)and 25.8%(8/31)in group A,group B and group C,respectively.There was significant difference among three groups(χ2=15.548,P<0.001).Group comparison of group A and group B as well as group A and group C showed statistical significance(χ2=8.139,P=0.004;χ2=16.508,P<0.001),but the difference between group B and group C was not significant(χ2=1.216,P=0.270).Conclusion Increased D-D is valuable for diagnosis of atelectasis in children with MP.%目的 探讨D-二聚体(D-D)在支原体肺炎所致肺不张中的临床意义.方法 回顾性收集2012年1月至2013年12月在北京市通州区妇幼保健院儿科住院的103例支原体肺炎患儿临床资料,分析入院患儿D-D值与治疗后肺不张发生率的关系.结果 103例支原体肺炎患儿依据D-D结果分为A组(D-D<0.25μg/mL,52例),B组(D-D>0.25μg/mL~<1.0μg/mL,20例)和C组(D-D≥1.0μg/mL,31例).A、B、C三组患儿肺不张的总发生率为10.7%(11/103),A组肺不张发生率0(0/52),B组肺不张的发生率15.0%(3/20),C组肺不张的发生率25.8%(8/31),三组患儿肺不张发生率的差异具有统计学意义(χ2=15.548,P<0.001).将两组之间肺不张发生率进行比较,A组与B、C组相比差异有统计学意义,A与B组比较:χ2=8.139,P=0.004,A与C组相比:χ2=16.508,P<0.001,但B与C组相比无统计学差异:χ2=1.216,P=0.270.结论 D-D升高对于儿童支原体肺炎发生肺不张有重要临床意义.