Objective To explore the risk of osteoporosis (OP) in elderly women with common chronic diseases and analyze the effect of comprehensive intervention on quality of life.Methods Elderly women (≥60years) visiting 187th Hospital of PLA from May2017to March 2018were selected as study objects, and divided into four groups according to whether suffering from common chronic diseases, including diabetes mellitus group (DM group), chronic obstructive pulmonary disease group (COPD group), cardio-cerebrovascular disease group and normal group with 25cases in each group.Bone mineral density (BMD) of different parts (lumbar spine, hip and the left forearm distal radius) in 4groups were detected and compared.Whoqol-100quality of life scale was used to evaluate the quality of life of all patients with OP after 3 months of comprehensive intervention.Results There was significant difference in prevalence of OP among 4groups checked by Fisher's exact probability method (P＜0.01), with highest prevalence of OP in COPD group (100.00％) and lowest in normal group (52.00％).Further Fisher's exact probability check analysis found that prevalence of OP in COPD group was significantly higher than that in other three groups (all P＜0.01), but there was no significant difference in prevalence of OP among DM group, cardio-cerebrovascular disease group and normal group (χ2=0.325, P=0.850).There were significant differences in bone mineral contents of lumbar spine, hip and left forearm distal radius among 4groups (Fvalue was 2.543, 2.228and 3.937, respectively, all P＜0.05).Further analysis revealed that mineral contents in lumbar spine, hip and left forearm distal radius in COPD group were significantly lower than those in other three groups (t value ranged 2.213-3.097, all P＜0.05), while there were no significant differences among DM group, cardiocerebrovascular disease group and normal group (Fvalue was 0.334, 0.457and 0.214, respectively, all P＞0.05).Thirty-three patients diagnosed with OP in four groups accepted intervention treatment, and survey results found that overall quality of life score significantly increased after intervention (t=3.66, P＜0.05), and physical, psychological, environmental, independence and mental health scores were all significantly increased (t value ranged 2.41-3.91, all P＜0.05).Conclusion Elderly women with COPD are prevalent population of OP fractures, and prevention of fracture and comprehensive intervention should be done as soon as possible.%目的探讨老年常见慢性病女性骨质疏松发病风险,并分析综合干预对生活质量的效果.方法选择2017年5月至2018年3月在解放军第187医院就诊的老年女性(≥60岁)为研究对象,根据是否患有常见慢性病分为糖尿病组(DM组)、慢性阻塞性肺部疾病组(COPD组)、心脑血管病组、正常组,每组各25例,比较各组不同部位(腰椎、髋部、左手前臂桡骨远端)的骨密度(BMD).对所有骨质疏松(OP)患者进行综合干预治疗3个月,采用WHOQOL-100生存质量量表对其生活质量进行评价.结果经Fisher确切概率法检验,四组间OP患病率比较有显著性差异(P＜0.01),其中以COPD组患病率最高(100.00％),正常组最低(52.00％),进一步经Fisher确切概率法检验分析后发现COPD组OP患病率均显著高于其他三组(均P＜0.01),DM组、心脑血管病组和正常组间OP患病率比较无显著性差异(χ2=0.325,P=0.850).四组间腰椎、髋部、左手前臂桡骨远端部位骨矿含量比较均有显著性差异(F值分别为2.543、2.228、3.937,均P＜0.05),对数据进一步分析后发现,COPD组腰椎、髋部、左手前臂桡骨远端部位骨矿含量均显著低于其他三组(t=2.213～3.097,均P＜0.05),而DM组、心脑血管病组、正常组上述3个部位骨矿含量比较无显著性差异(F值分别为0.334、0.457、0.214,均P＞0.05).对四组中共33例诊断为OP的患者进行综合干预治疗,结果发现干预后总体生活质量评分显著提高(t=3.66,P＜0.05),且生理、心理、环境、独立性和精神方面各项评分均显著提高(t=2.41～3.91,均P＜0.05).结论COPD组是老年女性骨质疏松骨折的好发人群,应及早做到预防骨折的发生及综合干预.
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