重离子注入法诱变维生素B_（12）高产菌株

摘要

Vitamin B12 producing strain 2009 - 106 was mutated by 50 Gy heavy ion into strain 106 - 8. Compared with the original strain 2009 -106, the relative flask potency of strainl06 -8 increased 31%. After optimization of fermentation medium, it was used in 120 tons fermentation can, and increased production obviously.%维生素B12生产菌2009-106株经重离子50 Gy诱变处理得106-8株,其摇瓶单位较出发菌株2009-106提高了31%,对其发酵培养基优化后,应用于120吨发酵罐生产,明显提高产量。