为了解潮霉素B预混剂临床驱除绦虫线虫的有效性和给药时间的合理性,依据兽药临床试验规范,试验选择了蠕虫自然感染皖西麻黄鸡824只,按要求随机分为3组,分别为潮霉素B预混剂治疗组284只,芬苯哒唑粉对照药物组284只,不治疗的感染对照组256只,试验周期根据临床治疗效果确定.结果显示,潮霉素B预混剂,推荐剂量10 mg/kg混饲,连续饲喂21 d,对鸡蛔虫和绦虫的粗计驱虫率分别为63％和26％,表现明显的驱除蛔虫作用(P<0.05),连续饲喂42 d,对鸡蛔虫和绦虫的粗计驱虫率分别为100％和-13％,驱蛔虫效果极显著(P<0.01);对照药物芬苯哒唑粉,50 mg/kg混饲,连续饲喂6 d,对鸡蛔虫和绦虫的粗计驱虫率分别为100％和44％,同样具有极显著的驱除蛔虫作用(P<0.01),本试验中2种药物的驱蛔虫效果相当,对绦虫的驱除作用不明显(P>0.05).潮霉素B预混剂10 mg/kg混饲,连续饲喂42 d,可以驱净鸡蛔虫的感染,但对鸡绦虫感染无明显的驱除作用.%To understand the clinical effect and rational administration time of hygromycin B premixs expelling the Taenia and Nematodes,824 Wanxi partridge chicken naturally infected by worms were selected and randomly assigned to three groups: the hygromycin B premixes treatment group(n=284),the fenbendazole powder control drug group(n=284)and the no treatment and infected control group(n=256).The test period is determined according to the clinical effect.The results showed that when 10 mg/kg hygromycin B premixes was fed continuously for 21 days,the deworming rate in chicken roundworms and tapeworms was about 63％ and 26％,respectively,showing a significant effect on expelling roundworms(P<0.05).When fed continuously for 42 days,the rough deworming rate in chicken roundworms and tapeworms was 100％ and-13％,respectively,showing an extremely significant effect on expelling roundworms(P<0.01).The coarse deworming rate in chicken roundworms and tapeworms with 50 mg/kg control drug fenbendazole powder feeding continuously for six days was 100％ and 44％,respectively,also showing an extremely significant role in expelling roundworms(P<0.01).In the test,the effect of these two drugs driving out roundworms was similar,while their role in expelling tapeworms was not obvious(P>0.05).10 mg/kg hygromycin B premixs with feeding continuously for 42 days can dispel chicken roundworms completely,but has no obvious effect on expelling chicken tapeworms.
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