首页> 外国专利> COMPUTATIONAL PATHOLOGY APPROACH FOR RETROSPECTIVE ANALYSIS OF TISSUE-BASED COMPANION DIAGNOSTIC DRIVEN CLINICAL TRIAL STUDIES

COMPUTATIONAL PATHOLOGY APPROACH FOR RETROSPECTIVE ANALYSIS OF TISSUE-BASED COMPANION DIAGNOSTIC DRIVEN CLINICAL TRIAL STUDIES

机译:基于组织的同伴诊断驱动临床试验研究的回顾性分析的计算病理学方法

摘要

Automated systems and methods are presented for retrospectively analyzing clinical trial data. A plurality of image derived from biological samples of patients in a cohort population are accessed. Image features are computed based on the plurality of images. A diagnostic feature metric is derived based on the computed image features. A cut point value is determined by applying a statistical minimization method using the derived diagnostic feature metric and patient outcome data from the cohort population, in which the cut point value identifies a patient in the cohort population as positive or negative for a diagnostic test.
机译:提出了用于回顾性分析临床试验数据的自动化系统和方法。访问了来自队列人群中患者的生物样品的多个图像。基于多个图像计算图像特征。基于所计算的图像特征来导出诊断特征度量。通过使用统计最小化方法使用派生的诊断特征量度和来自该队列人群的患者结果数据来确定切点值,其中,该切点值将队列人群中的患者标识为诊断测试的阳性或阴性。

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