Objective To study the therapeutic effects of multidisciplinary treatments based on sequential endarterectomy on thromboangiitis obliterans (TAO). Methods Patients diagnosed as TAO in the First Hospital Affiliated to Harbin Medical University from August 2008 to December 2014 were randomly divided into sequential endarterectomy group (32 cases) and sequential endarterectomy combined with lumbar sympathectomy group (combined group, 34 cases). A multidisciplinary approach was applied in all patients. Results The ankle brachial index (ABI) at 6, 12 and 24 months after surgery of two groups were significantly higher than pre-operation(P<0.05), while Rutherford classification were significantly improved after surgery(P<0.05). ABI at 12 and 24 months after surgery in combined group were higher than that in sequential endarterectomy group (P<0.05), while Rutherford classification values at 24 months after surgery in combined group w ere lower than that in sequential endarterectomy group (P<0.05). Conclusion Multidisciplinary treatments based on sequential endarterectomy is beneficial to patients by increasing limb salvage rate as well as improving the quality of life of patients.%目的 探讨以序贯法内膜剥脱手术为基础的多学科综合治疗下肢血栓闭塞性脉管炎(TAO)的临床疗效.方法 对哈尔滨医科大学附属第一临床医院2008年8月至2014年12月间收治66例下肢TAO患者按照入院顺序随机分两组采用序贯法内膜剥脱术(32例)和序贯法联合腰交感神经节切除术(34例),结合多学科综合治疗来分析其疗效.结果 序贯法内膜剥脱组和联合组术后随访6、12和24个月ABI值均明显升高(P<0.05),Rutherford分级值均明显降低(P<0.05).联合组患者术后12、24个月ABI高于序贯法内膜剥脱组(P<0.05),术后24个月Rutherford分级值低于序贯法内膜剥脱组(P<0.05).结论 以序贯法内膜剥脱手术为基础的多学科综合治疗下肢血栓闭塞性脉管炎能使患者明显获益,增加保肢率,提高患者的生活质量.
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