Objective To detect new ultrasound signs of the fetal atrial septal aneurysm (FASA), echocardiography was performed to study the morphology and hemodynamics of FASA. We expected to determine and evaluate objective indicators and prognosis of FASA. Methods 12 cases of FASA fetuses were selected as the study group and 30 fetuses of approximate gestational age and normal foramen ovale (FO) were selected as the control group. Observe TDE and CDFI ultrasound signs of the FO. The two groups were compared by the parameters of FO. In the same period after childbirth, the study group and the control group were compared in the FO closure rate and FO various parameters. Results There is significant discrepancy in fetal FO peak blood flow velocity, left and right atrium maximum pressure gradient and aneurysm mass effect between the FASA group and the control group. In the 12 cases of FASA fetuses, one had adverse outcome and was terminated pregnancy, adverse outcome of fetuses in the FASA accounted for 8. 33% (1/12). The other 11 cases of term delivery had good recovery, accounting for 91. 67% (11/12). At the end of the first month of postpartum, infants' FO closure rate of the two groups was statistically significant difference; FO blood flow peak velocity, left and right atrium maximum pressure gradient of the difference were not statistically significant. At the end of the 2nd to the 6th month of postpartum, there was no significant discrepancy between the two groups in FO closure rate, FO peak blood flow velocity, left and right atrium maximum pressure gradient. Conclusions Mass effect is specific signs of FASA in the four-chamber view of fetal heart. Color Doppler echo-cardiography is the best means of diagnosis of FASA. FASA alone is a short-term process of the development of some fetuses and should not be treated as malformation and terminated. FASA fetuses without complications have good outcome.%目的 应用多普勒超声对胎儿房间隔膨出瘤(FASA)进行形态学及血流动力学检测,并进行出生后超声随访,以探讨FASA的声像图特征及评价FASA预后的客观指标.方法 以产前检出的12例FASA胎儿为研究组,以30例胎龄近似、卵圆孔正常的胎儿为正常对照组,比较两组之间卵圆孔各项参数之间的差异.在产后同一时间段,比较研究组与对照组两者婴儿之间卵圆孔闭合率、卵圆孔各参数之间的差异.结果 FASA组与对照组胎儿卵圆孔峰值血流速度及左右心房最大压力阶差、膨出瘤占位效应均具有显著性差异.12例FASA胎儿中,1例结局不良并终止妊娠,占8.33％ (1/12).其余11例足月分娩,恢复良好,占91.67％ (11/12).产后第1个月末2组婴儿卵圆孔闭合率差异具有统计学意义,卵圆孔峰值血流速度、左右心房最大压力阶差的差异无统计学意义.产后第2至第6个月末,2组婴儿的卵圆孔闭合率、卵圆孔峰值血流速度、左右心房最大压力阶差比较均无统计学意义.结论 胎儿心脏四腔心切面房间隔膨出瘤具有占位效应是FASA的特异性超声征象,彩色血流超声心动图是诊断FASA的最佳手段；单纯的FASA是部分胎儿发育过程中短期过程,不应作为畸形而引产,没有合并症的FASA结局良好.
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