不同病因肝硬化患者肝实时剪切波弹性成像测值范围比较

摘要

目的：分析不同病因的肝硬化患者肝杨氏模量值是否有差异。方法收集经临床确诊的肝硬化失代偿期患者199例,其中乙型肝炎后肝硬化患者139例,丙型肝炎后肝硬化患者26例,酒精性肝硬化患者34例。选择同期50名健康志愿者作为健康对照组。所有受试者均进行肝实时剪切波弹性成像检查,测量并记录肝组织的杨氏模量值,分析比较各组受试者肝组织的杨氏模量值差异。结果健康对照组的肝组织杨氏模量值最低,为(4.81±0.9)kPa。乙肝后肝硬化组、丙肝后肝硬化组、酒精性肝硬化组的肝组织杨氏模量值依次增高,分别为(16.3±8.9)kPa、(17.8±4.8)kPa、(30.6±12.3)kPa,组间差异有统计学意义(F =27.95,P <0.01)。结论实时剪切波弹性成像技术测量的不同病因肝硬化患者的肝组织杨氏模量值有一定的差异。%Objective To analyze the difference of Young's modulus between cirrhotic patients with different etiologies.Methods There were 1 99 patients with decompensated cirrhosis enrolled in this study, all of them had been diagnosed clinically.There were 139 cases of hepatitis B patients with cirrhosis,26 cases of hepatitis C patients with liver cirrhosis,34 cases of patients with alcoholic cirrhosis,and selected 50 healthy volunteers as control group in the same period.All subj ects underwent liver shear wave elastography examination,measured and recorded the Young's modulus,and compared the difference between each groups.Results The Young's modulus of liver in the healthy control group was (4.81±0.9)kPa,which was lowest in all groups.The Young's modulus of hepatitis B cirrhosis,hepatitis C cirrhosis,alcoholic cirrhosis increased successively,which was (16.3±8.9)kPa,(17.8±4.8)kPa,(30.6±12.3)kPa,respectively,and the difference between the groups was statistically significant(F =27.95,P <0.01).Conclusions There were some differences of the Young's modulus of cirrhotic patients with different etiologies by real-time shear wave elastography.