头穴透刺治疗对血管性痴呆患者血清TNF-α、IL-1β的影响

摘要

Objective:To observe the curative effect of scalp penetration onpatients with vascular dementia and the effects of TNF-α and IL-1βlevels in serum.Methods:80 patients of vascular dementia were randomly divided into observation group and control group with each 40 patients,the observation group was treated with the scalp penetration and Nimodipine Tablet,the control group was treated with Nimodipine Tablets,30 days was one treatment course,they were treated for three courses.The curative effect was evaluated by the simple mental state checklist (MMSE),the contents of TNF-α and IL-1βin serum were determined by ELISA.Results:The curative effect and MMSE score of the observation group were significantly better than those of the control group,the differences were statistically significant (P ＜ 0.05).The levels of serum TNF-α and IL-1 βin theobservation group were lower than those in the control group,the differences were statistically significant (P ＜ 0.05).Conclusion:the scalp penetration can improve the curative effect of patients with vascular dementia,decreasing the levels of serum TNF-α and IL-1 βmaybe part of its mechanism.%目的:观察头穴透刺治疗血管性痴呆的临床疗效及其对血清TNF-α、IL-1β水平的影响.方法:将80例血管性痴呆患者按就诊顺序随机分为观察组和对照组各40例,观察组采用头穴透刺+尼莫地平片治疗,对照组采用尼莫地平片治疗,30 d为1疗程,共治疗3个疗程.采用简易智力状态检查量表(MMSE)评分进行疗效评定并ELISA法测定治疗前后血清TNF-α、IL-1β的含量.结果:观察组临床疗效及MMSE评分明显优于对照组,差异具有统计学意义(P＜0.05).观察组治疗后血清TNF-α、IL-1β水平较对照组降低明显,差异具有统计学意义(P＜0.05).结论:头穴透刺可以提高血管性痴呆患者的临床疗效,降低血清TNF-α、IL-1β是其部分作用机制.