背景:以介绍第65届美国运动医学会 (ACSM) 年会暨第9届运动是良医世界科学大会、肌肉肥大和萎缩世界大会中研究热点之一的肌萎缩的机制及临床研究为研究目的.目的:着重针对肌萎缩研究成果的前沿和热点进行归纳和分析, 为更深入的探究其机制和应用以及运动对肌肉功能影响提供思路, 同时为中国体育科学、运动医学及运动康复研究提供参考.方法:整理第65届美国运动医学会年会中相关报道及前沿研究成果, 并结合检索PubMed等数据库1993年1月至2018年8月相关文献研究, 检索词为"skeletal muscle, muscle atrophy, movement and muscle, resistance movement".纳入与肌肉萎缩的分子机制及肌萎缩临床应用的相关文献35篇进行分析讨论.结果与结论:今年肌肉肥大和萎缩世界大会是召集跨学科研究人员参加的、该领域水平最高的学术会议, 议程包括该领域的主要专家的主题演讲、教程讲座和专题研讨, 重点关注引起肌肉肥大和萎缩发生的分子机制、内在与外在影响因素.其中, 会议对运动如何导致骨骼肌萎缩以及在衰老、疾病、损伤、慢性病等临床问题中的应用, 以及这些变化与慢性病的联系都进行了探讨.而肌肉肥大的相关研究更多集中在竞技体育领域.%BACKGROUND: The purpose of this study was to introduce the mechanism and clinical application of muscular atrophy that is a hotspot in the 65th Annual Meeting of American College of Sports Medicine and the 9th World Conference on Exercise Is Medicine and the World Conference of Basic Science of Muscle Hypertrophy and Atrophy. OBJECTIVE: To summarize and analyze the frontiers and hotspots of research findings on muscular atrophy, in order to provide new ideas for further research of exercise improving muscle function and the mechanism and application in this field, and provide a reference for the study on sports science, sports medicine, and sports rehabilitation in China. METHODS: Related reports and cutting-edge research findings in 65th Annual Meeting of American College of Sports Medicine were collected. Meanwhile, PubMed database between January 1993 and August 2018 was retrieved. The keywords were "skeletal muscle, muscle atrophy, movement and muscle, resistance movement". Thirty-five articles related to the molecular mechanism and clinical application of muscle atrophy were included for analysis and discussion. RESULTS AND CONCLUSION: The World Congress is a unique opportunity to bring together interdisciplinary investigators for the most comprehensive meeting ever held on this topic. The program will include a keynote lecture, tutorials, and symposia from leading experts. The meeting focused on the intrinsic and extrinsic variables that regulate skeletal muscle hypertrophy and atrophy. How exercise brings about skeletal muscle atrophy and its application in clinical problems such as aging, disease, injury, chronic diseases, and how these changes may relate to chronic disease were discussed as well. The research on muscle hypertrophy is mostly concentrated in the field of competitive sports.
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