维生素D及其受体与毛发的关系

摘要

背景:越来越多的研究发现,维生素D及其受体与毛发有一定关系.目的:全面阐述维生素D及其受体与毛囊干细胞、毛发生长周期、信号转导以及脱发性疾病等的关系.方法:应用计算机以"维生素D、维生素D受体、毛发、脱发、基因多态性"或"vitamin D,vitamin D receptor,hair,alopecia,gene polymorphism"为检索词检索PubMed和CNKI数据库1990/2011-11发表的关于维生素D及其受体与毛发关系的文章,同一领域选择近期发表或发表在权威杂志上的文章.结果与结论:初检得到152篇文献,根据纳入排除标准选择30篇文章进行综述.目前研究显示,维生素D及其受体在毛发中扮演重要角色,其异常可导致脱发等疾病的产生,为预防和治疗脱发性疾病提供新的可能,并有望在未来广泛应用.%BACKGROUND: Increasing evidence has demonstrated that vitamin D and its receptor correlate with hair.OBJECTIVE: To fully discuss the relationship between vitamin D, vitamin D receptor and hair follicle stem cells, hair cycle, signaltransduction and alopecia.METHODS: A computer online retrieval was performed in PubMed and CNKI database to search papers addressing therelationship between vitamin D, vitamin D receptor and hair published between November 1990 and November 2011 with the keywords " vitamin D, vitamin D receptor, hair, alopecia, gene polymorphism" in Chinese or English. Papers published recently or inthe authoritative journals were selected.RESULTS AND CONCLUSION: A total of 152 papers were initially retrieved. According to inclusion and exclusion criteria, 30papers were selected. The current studies have shown that vitamin D and its receptor play an important role in hair and thedisorder of vitamin D would lead to alopecia. Regulation of vitamin D and its receptor may be successful in preventing andtreating hair disorders and is promising in future use.