BACKGROUND:Chitosan has an excelent performance, such as non-toxic, non-irritating, biocompatibility and biodegradability, which can promote adhesion and proliferation of a variety of tissue cels. Chitosan has become a research hotspot in the tissue engineering scaffold. OBJECTIVE:To investigate the application development of chitosan and its derivative scaffolds in tissue engineering. METHODS: A computer-based search of China Biology Medicine Database and PubMed was performed for articles related to chitosan and its derivative scaffolds published from 1989 to 2013. The keywords were “chitosan, scaffold, tissue engineering” in Chinese and English, respectively. RESULTS AND CONCLUSION:There are several aspects about the major use of chitosan and its derivative scaffolds for tissue engineering. One is to act as a cel culture scaffold; the second is to act as a compound scaffold which is combined with other materials; and the third is to be used as a modified scaffold. Chitosan and its derivatives are a kind of natural polymer material which has unique biological activity. It has broad application prospects in tissue engineering research. To be combined with other biomaterials or to prepare modified scaffolds wil be the future research focus of chitosan and its derivatives.%背景：壳聚糖具有无毒性、无刺激性、生物相容性、生物可降解性等优良性能，对多种组织细胞的黏附和增殖具有促进作用，目前已成为组织工程学支架研究方面的一个热点。 目的：综述壳聚糖及其衍生物支架在组织工程上的应用进展。 方法：应用计算机检索中国生物文献数据库及PubMed数据库1989至2013年，有关壳聚糖及其衍生物支架在组织工程中应用的文献，关键词为“壳聚糖，支架，组织工程；Chitosan，scaffold， tissue engineering”。结果与结论：壳聚糖及其衍生物支架在组织工程中的应用主要集中在几方面：作为细胞培养支架；与各种材料形成复合支架使用；改性壳聚糖支架。壳聚糖及其衍生物是一类有独特生物活性的天然高分子材料，在组织工程研究中有广阔的应用前景，与其他生物材料组成复合材料及制成改性支架将是它今后的研究重点。
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