背景：利用骨髓间充质干细胞在特定的诱导条件下可分化为成骨细胞的特性，直接在骨折骨不连部位进行自体骨髓间充质干细胞移植，这一新技术受到广大骨科临床医师的关注。 目的：总结分析采用骨髓间充质干细胞移植治疗四肢骨折骨不连的临床疗效。 方法：检索1998至2014年西文生物医学期刊文献数据及CNKI数据库有关骨髓间充质干细胞移植治疗四肢骨折骨不连的文献，英文检索词为“bone marrow stem cel s(BMSCs),stem cel transplantation(SCT), nonunions,tissue engineering”，中文检索词为“骨髓间充质干细胞，干细胞移植，骨不连”。排除内容重复和缺乏原创性文献，保留36篇文献做进一步分析。 结果与结论：将骨髓间充质干细胞移植到骨不连断端骨组织，可诱导其分化为成骨细胞来修复骨不连、骨缺损，为临床应用奠定了理论基础。骨髓间充质干细胞具有明确的骨缺损修复能力，众多研究表明采用骨髓间充质干细胞移植治疗四肢骨折骨不连是安全、有效的。%BACKGROUND:As bone marrow mesenchymal stem cel s can be differentiated into osteoblasts under certain induction conditions, autologous bone marrow mesenchymal stem cel s can be implanted into the bone nonunion site of bone fracture. This new technology garners increasing attention of orthopedic clinicians. OBJECTIVE:To summarize the clinical efficacy of transplantation of bone marrow mesenchymal stem cel s in the treatment of bone nonunion of limb fractures. METHODS:A computer-based search of Foreign Medical Journal Ful-Text Service and CNKI databases was performed for articles related to bone marrow mesenchymal stem cel s for treatment of bone nonunion of limb fractures published from 1998 to 2014 using the keywords of“bone marrow stem cel s (BMSCs), stem cel transplantation (SCT), nonunions, tissue engineering”in English and Chinese, respectively. Literatures with repetitive content and lack of originality were excluded. A total of 36 literatures were obtained for further analysis. RESULTS AND CONCLUSION:Bone marrow mesenchymal stem cel s are transplanted into the end of bone nonunion, and then can be induced to differentiate into osteoblasts to repair bone nonunion and bone defects, laying a theoretical basis for clinical application. Bone marrow mesenchymal stem cel s can repair bone defects, which provides an effective method and material to promote fracture healing. Transplantation of bone marrow mesenchymal stem cel s is safe and effective for treatment of bone nonunion of limb fracture.
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