BACKGROUND:Epidermal stem cells as special stem cells of the skin not only plays an important role in maintaining the metabolism of skin, but also is closely related to wound repair, which are the basis for the occurrence and repair of skin and its appendages. Now, epidermal stem cells have been paid great attention on the research of gene therapy and celltherapy with its specific biological advantages. OBJECTIVE:To summarize the research status on features and clinical application of epidermal stem cells. METHODS:A computer-based online retrieval of CNKI, PubMed database and Google scholar was performed for searching papers about clinical application of epidermal stem cells using the keywords of“epidermal stem cells, stem cells division, stem cells culture, clinical application”in Chinese and English. Older theoretical perspectives and repetitive research were excluded. Finally, only 41 articles were included in result analysis. RESULTS AND CONCLUSION:Epidermal stem cells have the great potential of proliferation and multi-directional differentiation, and have important significances for large-area skin defects (burn and trauma), skin tissue engineering, and gene therapy. There are stil many problems that need to be solved, such as how to screen surface markers special for epidermal stem cells and how to induce skin differentiation of epidermal stem cells.%背景：表皮干细胞作为皮肤组织的特异性干细胞，不仅是维持皮肤新陈代谢的主要功能细胞，而且与创面修复紧密相关，是皮肤及其附属器发生、修复的基础。现在表皮干细胞凭借其特有的生物学优势在基因治疗、细胞治疗中越来越受到重视。目的：对表皮干细胞的特性及临床应用研究现状进行综述。方法：应用计算机检索 CNKI、 PubMed 数据库以及进行Google学术搜索，检索词为“表皮干细胞，临床应用，干细胞分裂；干细胞培养；epidermal stem cel s，stem cel s division，stem cel s culture，clinical application”。排除较陈旧的理论观点以及重复性研究，最后纳入41篇文献。结果与结论：表皮干细胞作为皮肤组织的特异性干细胞，是维持皮肤新陈代谢的主要功能细胞和皮肤及其附属器发生、修复、改建的基础。表皮干细胞研究已显示出巨大的临床应用前景，对烧伤、创伤等大面积皮肤缺损的治疗以及组织工程皮肤、基因治疗等方面都有重大意义。目前在表皮干细胞研究领域里仍有很多问题需解决，例如如何筛选公认的具有表皮干细胞特异性的表面标志物，如何诱导表皮干细胞朝着特定的皮肤结构进行分化等。
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