骨诱导活性材料修复牙槽突裂骨缺损的可行与可靠性

摘要

BACKGROUND:In clinic, bone grafting can be adopted to treat alveolar bone defect, and the selected bone graft materials wil have a certain impact on the ultimate effect of bone grafting. OBJECTIVE:To explore the feasibility and reliability of osteoinduction active materials in the repair of alveolar cleft defects. METHODS:A total of 63 patients with alveolar cleft defect, including 33 male and 30 female patients, aged 8 to 15 years, were enroled and treated by bone grafting. Patients were divided into autologous bone group (n=32) and osteoinduction active material group (n=31) according to different bone graft materials. During 12 months of folow-up after the treatment, the bone grafting effect, bone density, canine condition and adverse reactions were observed. RESULTS AND CONCLUSION:There was no significant difference in the total effective rate between the autologous bone and osteoinduction active material groups (P > 0.05). Among the seven unerupted canines in the autologous bone group, two teeth erupted, four moved to the bone grafting area, and one appeared to have no obvious changes. Among the six unerupted canines in the osteoinduction active material group, two teeth erupted, two appeared to have no changes, and two moved to graft bone area. The bone density in these two groups was significantly increased after tooth restoration (P < 0.05). There was no significant difference in the bone density between these two groups after repair. Infection, rejection, bone graft loss and other adverse events did not occur in these two groups. These results demonstrate that the osteoinduction active materials in the treatment of alveolar cleft defects can achieve similar outcomes with the autologous bone graft, which has a certain clinical feasibility and reliability.%背景：临床可以采取植骨方式治疗牙槽骨缺损，其中所选用的植骨材料对最终植骨效果会产生一定的影响。目的：探讨骨诱导活性材料修复牙槽突裂骨缺损的可行性和可靠性。方法：纳入63例牙槽突裂骨缺损患者，其中男33例，女30例，年龄8-15岁，均实施骨移植治疗，按照所选用植骨材料的不同分为自体骨组(n=32)和骨诱导活性材料组(n=31)。治疗结束后随访12个月，观察两组植骨效果、骨密度、未萌尖牙情况及不良反应发生情况。结果与结论：①治疗总有效率：两组间比较差异无显著性意义(P>0.05)。②未萌尖牙情况：自体骨组7颗未萌尖牙中，2颗萌出，4颗向植骨区移动，1颗未出现明显改变；骨诱导活性材料组6颗未萌尖牙中，2颗萌出，2颗未出现明显改变，2颗向植骨区移动。③牙槽骨密度：两组修复后的骨密度均较治疗前显著增加(P<0.05)，修复后两组间比较差异无显著性意义。④不良反应：两组患者均未出现感染、排异及植骨材料脱落等不良事件。表明利用骨诱导活性材料修复牙槽突裂骨缺损可以获得与自体骨移植相似的效果，具有一定的临床应用可行性和可靠性。