毛囊干细胞在皮肤伤口修复中的促进作用

摘要

背景：毛囊干细胞来源于皮肤、毛发，数量极其可观，取材后无严重的并发症和免疫原性，可供自体移植，是最容易获取的干细胞来源之一。目的：综述毛囊干细胞促进皮肤伤口修复的作用因素，以期为该领域研究提供有效的实验依据。方法：应用计算机以“毛囊干细胞、皮肤修复、再生医学、组织工程”或“hair fol icle stem cel ，skin repairing， regenerative medicine，tissue engineering”为检索词检索CNKI 和 PubMed 数据库1999年1月至2014年12月发表的关于毛囊干细胞促进皮肤伤口修复的文章，最终选择45篇文章进行综述。结果与结论：毛囊干细胞作为一种容易获得、数量可观、使用较为安全以及具有分化潜能的成体干细胞，可以通过皮肤早期血管化、表皮及附属器官的再生、信号通路作用及转录因子调节等方面的影响，促进皮肤伤口的修复，能为再生医学及组织工程研究提供良好的种子细胞。%BACKGROUND:Hair fol icle stem cel s derived from skin and hair have the most readily available sources, and cannot lead to serious complications and immunogenicity after col ection, which can be used for autologous transplantation. OBJECTIVE:To provide effective experiment basis for hair fol icle stem cel s in the repair of skin wound through reviewing the role of hair fol icle stem cel s in promote the repair of skin wound. METHODS:Articles related to hair fol icle stem cel s for the repair of skin wound were retrieved in CNKI and PubMed databases (1999-01/2014-12). The key words were“hair fol icle stem cel , skin repairing, regenerative medicine, tissue engineering”in Chinese and English, respectively. A total of 45 articles based on inclusion criteria and exclusion criteria were obtained for the review. RESULTS AND CONCLUSION:Hair fol icle stem cel s belong to adult stem cel s, which are easy to access, have a significant number, and possess differentiation potential and safety. Hair fol icle stem cel s can promote the repair of skin wound and provides good seed cel s for regenerative medicine and tissue engineering research through early vascularization of the skin, epidermal and appendage regeneration, signaling pathways, and transcription factors.