Ghrelin对生长激素释放、成骨细胞增殖及骨生长的效应

摘要

背景:骨形成和骨吸收的平衡对维持骨量有重要作用,而内环境的稳定与平衡受多种因素影响,ghrelin作为调控生长激素分泌的主要激素之一,在骨重塑和机体能量代谢的调节中发挥重要作用.目的:综合分析ghrelin对生长激素释放的作用及其对及成骨细胞增殖、骨生长的影响.方法:检索PubMed和万方数据库检索1999至2016年有关ghrelin作用机制、ghrelin对成骨细胞增殖和骨代谢、骨重塑影响的相关中英文文献,排除重复文献.结果与结论:①Ghrelin参与了调节垂体生长激素的释放、调节能量代谢、调节炎症反应及参与骨形成等多种生物学功能;②Ghrelin对成骨细胞的分化增殖有促进作用,并可由软骨细胞分泌,参与骨代谢与生长;③Ghrelin可作为骨骼生长的一个重要靶点,但其作用机制复杂,还有待于进一步进行更深入的研究.%BACKGROUND: The balance between bone formation and bone resorption plays an important role in maintaining bone mass, and the stability and balance of the internal environment are affected by many factors.Ghrelin, a major hormone that regulates the secretion of growth hormone, plays a critical part in bone remodeling and body energy metabolism.OBJECTIVE: To investigate the effect of ghrelin on the release of growth hormone and its effect on osteoblast proliferation and bone growth.METHODS: PubMed and WanFang databases were retrieved for the Chinese and English literature addressing the mechanism of ghrelin and the effects of ghrelin on osteoblast proliferation, bone metabolism and bone remodeling published from 1999 to 2016. The repetitive articles were excluded.RESULTS AND CONCLUSION: Ghrelin is involved in the regulation of pituitary growth hormone release, energy metabolism, inflammatory response and osteogenesis. Ghrelin can promote the differentiation and proliferation of osteoblasts and can be secreted by chondrocytes, participating in bone metabolism and growth. Ghrelin can be used as an important target of bone growth, but its mechanism is complex and needs to be further studied.