Objective To study changes of coagulation function in patients with gastrointestinal bleeding induced by non-steroidal anti-inflammatory drugs (NSAIDs),and to explore treatment strategy.Methods 48 patients with gastrointestinal bleeding induced by NSAIDs and 50 patients without gastrointestinal bleeding treated with NSAIDs in our hospital from July 2014 to January 2016 were selected,they were marked as the observation group and the control group respectively,patients in the same group detected coagulation indexes [thrombin time (TT),prothrombin time (PT),activated partial thromboplastin time(aPTT),fibrinogen (Fbg)] expression level respectively,incidence of coagulation disorders in the two groups were observed and possible influencing factors were analyzed.Results There was no significant difference in TT、aPTT、PT、Fbg between the two groups (P ＞ 0.05),in the observation group,took aspirin as the priority,proportion was 64.6％,which was significantly higher than the control group(20％) (P ＜ 0.05);in the observation group,primary disease hypertension 58.3％,coronary disease 35.42％,diabetes mellitus 31.3％,cerebrovascular disease 14.6％ were significantly higher than the control group [28.0％,12.0％,14.0％,2.0％] (P ＜ 0.05).Conclusion Gastrointestinal bleeding is a common dangerous complications of NSAIDs,long-term use of aspirin,combined with hypertension,diabetes mellitus and other primary diseases are possible hazards of gastrointestinal bleeding with NSAIDs.%目的 研究非甾体类抗炎药(NSAIDs)致消化道出血患者的凝血功能变化,并探讨处理对策.方法 选取我院2014年7月至2016年1月期间因服用NSAIDs致消化道出血的48例患者和同期服用NSAIDs而未出现消化道出血的50例患者,分别记为观察组和对照组,由同组人员分别检测两组凝血指标[凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(aPTT)、纤维蛋白原(Fbg)]的表达水平,观察两组凝血功能障碍发生率并分析其可能影响因素.结果 两组TT,PT,aPTT,Fbg,均无显著差异(P＞0.05);观察服药种类中以阿司匹林为主,其比例为64.6％且较对照组20.0％高,差异显著(P＜0.05);观察组原发疾病高血压58.3％、冠心病35.42％、糖尿病31.3％、脑血管疾病14.6％分别较对照组28.0％、12.0％、14.0％、2.0％高,均差异显著(P＜0.05).结论 消化道出血是服用NSAIDs的常见危险并发症,长期服用阿司匹林、合并高血压、糖尿病等原发疾病很可能是服用NSAIDs患者出现消化道出血的危险因素.
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