以communesin F消旋体的全合成过程中的醛中间体为原料,在光学纯叔丁基亚磺酰胺的手性诱导下,通过加成和还原反应制得摩尔比为1:1的非对应异构体3a和3b;脱去3a的叔丁基亚磺酰基制得光学纯4; 4的氨基用Boc保护合成了光学纯Communesin F的重要中间体5.3~5的结构经1H NMR表征.%Under chiral induction of optically pure t-butanesulfinamide, a pair of diastereomers 3a and 3b with mole ratio of 1: 1 were synthesized from 1( an aldehyde intermediate in total synthesis of racemic communesin F) by addition reaction and subsequent reduction. 4 was prepared by deprotection of t-butanesulfinyl at 3a. Amido of 4 was protected with Boc to obtaine 5 (a key precursor in total synthesis of optically pure communesin F). The structures of 3 ~ 5 were characterized by 1 H NMR.
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