OPTICALLY PURE CAMPTOTHECIN ANALOGUES, OPTICALLY PURE SYNTHESIS INTERMEDIATE AND METHOD FOR PREPARING SAME

摘要

The invention relates to novel camptothecin analogs and in particular to products having the following formulas: (+) - 5-ethyl-9,10-difluoro-5-hydroxy-4,5,13,15-tetrahydro-1H, 3H - oxepino [3 ', 4': 6, 7] indolizino [1,2-b] quinoline-3,15-dione; (+) - 1- [9-chloro-5-ethyl-5-hydroxy-10-methyl-3,15-dioxo-4,5,13,15-tetrahydro-1H, 3H-oxepino [3 ', 4 ': 6.7] indolizino [1,2-b] quinolin-12-ylmethyl] -4-methyl-hexahydropyridinium; their use as medicaments, the pharmaceutical compositions containing them and their use for the production of antitumor, antiviral or antiparasitic drugs. It also relates to a new intermediate in the synthesis of the aforementioned products and a process for preparing said intermediate.