N-苄氧羰基-甘氨酸水飞蓟宾单酯的合成及其抗氧化活性

摘要

A novel silybin ester of iV-carbobenzyloxyglycine (2) was synthesized by DCC/DMAP coupling method by silybin(l) and iV-carbobenzyloxyglycine. The structure was characterized by UV, H NMR, IR and ESI-MS. The abilities of free radical scavenging and anti-lipid peroxidation were investigated by chemical and biological assays. The results showed that 2 exhibited good free radical scavenging and anti-lipid peroxidation at detecting concentration.%以水飞蓟宾(1)与N-苄氧羰基-甘氨酸为起始原料,采用DCC/DMAP促进偶合法合成了新型的N-苄氧羰基-甘氨酸-3-水飞蓟宾酯(2),其结构经UV,1H NMR,IR和ESI-MS表征.采用化学和生物学模型考察了2的清除自由基能力和抗脂质过氧化能力.结果表明,在测定浓度范围内,2具有较好的清除自由基能力和抗脂质过氧化能力.