修饰金鸡纳碱催化的不对称烯丙基烷基化反应

摘要

以修饰金鸡纳碱的手性叔胺为催化剂,Morita-Baylis-Hillman碳酸酯与α-取代的β-酮酸酯经不对称烯丙基烷基化反应,以中等收率及较好的非对映选择性和对映选择性合成了一系列具有连续季碳叔碳手性中心的新型烷基取代β-酮酸酯类化合物,其结构经1 H NMR和13C NMR表征.%Using modified cinchona alkaloid as the catalyst, a series of new compounds that bearing adjacent quaternary carbon and tertiary carbon chiral centers were synthesized by asymmetric allylic alkylation of Morita-Baylis-Hillman carbonates with α-substituted β-ketoesters in moderated yield with excellent diastereoselectivities and good enantioselectivities. The structures were characterized by 1H NMRand 13C NMR.