β-重氮-α-羰基酰胺类化合物的合成及其与烯烃的环丙烷化反应

摘要

A series of chiral 2-oxo-3-diazo amide alcohol' were synthesized from α-diazo-ethyl pyru vates and amino alcohols by the reaction of ammonolysis, their cyclo-propanation reactions with sim ple alkene to gave β-cyclopropyl-α-ketoamides bearing multiple handles for further chemical transfor mations. The structures were confirmed by 1H NMR, 13C NMR, IR and HR-MS.%以重氮丙酮酸乙酯和氨基醇为原料,经过氨解合成了一系列β-重氮-α-羰基酰胺类化合物,并与环己烯反应制备了环丙烷化产物,其结构经1H NMR,13C NMR,IR和HR-MS确证.