3-O-乙酰基-4,6-二-O-苄基-1,2-环丙烷葡萄糖的合成

摘要

以葡萄糖为起始原料制得苄基葡萄烯糖,再经Ferrier重排、双羟化反应、选择性磺酰化、羟基保护和在碱性条件下关环反应合成了3-O-乙酰基-4,6-二-O-苄基-1,2-环丙烷葡萄糖.其中5个中间体为新化合物,其结构经1H NMR,13C NMR和HR-MS表征.%3-O-acetyl-4,6-di-0-benzyl-l ,2-cyclopropaneacetylated glycose was synthesized by a five step reaction of Ferrier rearrangement, dihydroxylation, selective sulfonylation, hydroxyl protection and ring formation under basic condition from tri-0-benzyl-D-glucal. Five intermediates of them were new compounds which the structures were characterized by 1H NMR, 13C NMR and HR-MS.