Ⅱ型内漏连续测压动物模型的建立

摘要

目的 采用有线压力传感器结合补片,建立腹主动脉瘤腔内修复术后Ⅱ型内漏连续测压动物模型.方法 家猪9只,随机分为实验组6只,对照组3只.建立腹主动脉瘤模型时实验组保留肾下第2、第3对腰动脉作为反流动脉,对照组结扎上述动脉.对家猪行腔内修复术,在主动脉植入人工血管支架.CT血管造影寻找内漏,造影排除Ⅰ型和Ⅲ型内漏.有线压力传感器测定隔离腹主动脉瘤内压力,通过对比实验组和对照组动脉瘤内压力变化,评价实验组Ⅱ型内漏效果.结果 9只家猪成功建立腹主动脉瘤测压动物模型.腔内修复术后,CT血管造影证实实验组均形成内漏,腰动脉反流通畅.比较术后与术前平均压的比值,实验组高于对照组(U=0.000,P=0.020).比较术后动脉压与术前平均压的比值,实验组高于对照组(U=0.000,P=0.020).结论 保留腰动脉作为反流动脉可以建立Ⅱ型内漏家猪模型,用有线压力传感器以补片法可以建立腹主动脉瘤腔内修复术后测压模型.%Objective To develop a type Ⅱ endoleak porcine model with continuous pressure monitor by the strain-gauge pressure transducer and the patch.Methods Nine tamed porcine was randomized as the experiment group of 6 domesticated pigs and the control group of 3 domesticated pigs.When the abdominal aortic aneurysm(AAA)was created,the 2nd and 3rd pair of infrarenal lumber arteries were preserved in the experiment group,while ligated in the control group.The stent-graft was implanted in the endovascular repair.CT angiography was performed to seek endoleak,and the angiography was performed to excluded the type Ⅰ and type Ⅲ endoleak.The pressure in the excluded AAA monitored by the straingauge pressure transducer was recorded and compared in both groups to evaluated the effect of type Ⅱ endoleak in the experiment group.Results The AAA porcine model with pressure monitor were successfully developed in all 9 porcine.The endoleak and the retrograde flow of the lumber arteries were confirmed by CT angiography in the experiment group.The ratio of the average pressure after the procedure to before the procedure was higher in the experiment group than the control group(U =0.000,P =0.020).The ratio of the pulse pressure after the procedure to the average pressure before the procedure was higher in the experiment group than the control group(U =0.000,P =0.020).Conclusion It is feasible to develop type Ⅱ endoleak domesticated pig model by preserving the lumber arteries for the retrograde flow,and the AAA model with pressure monitor by the strain-gauge pressure transducer and the patch.