基质金属蛋白酶调节神经血管单元影响慢性压迫性脊髓损伤转归的机制研究进展

摘要

Chronic spinal cord compression is the common clinical prognosis with various outcomes,but the affecting factors and mechanisms still remain unexplored.The structure and function of neurovascular unit manifest great significance in the central nervous system diseases.This paper discusses matrix metalloproteinase (MMP) impact on the stability of the neural vascular unit,by directly decomposing extracellular matrix,inducing the glial cell migration,activating angiogenesis,regulating function of blood spinal cord barrier,and put forward the MMP may be the key points in regulation of spinal cord neurovascular unit structure and function change to affect the outcome of chronic oppressive cervical spinal cord.%慢性脊髓压迫临床常见而预后呈多样性特点,而决定不同转归的因素和机制尚不明确.神经血管单元结构和功能变化在中枢神经系统疾病中有重要意义.基质金属蛋白酶(MMP)通过直接分解外基质、诱导胶质细胞迁徙、参与调节新生血管化、调控血脊髓屏障功能,进而影响神经血管单元稳定.MMP参与调控脊髓神经血管单元结构和功能变化可能是影响颈脊髓慢性压迫性损害转归的重要环节.