目的：研究能够提高艾地苯醌生物利用度，并延长其体内循环时间的纳米脂质载体系统，运用透析袋扩散法，考察其体外释放特性。方法：通过研究不同形式的艾地苯醌载药方式（纳米结构脂质载体(NLC)、纳米乳(NE)及其水凝胶）在不同的环境（PH1.2、PH6.8、PH7.4）以及不同的摇床转速等变量情况下的体外释放特性，得以模拟在胃液、肠液和体液环境下，脂质纳米载体、水凝胶的缓释和控释性能。结果：艾地苯醌不同载药方式体外释放特性不同，NE剂型的释放速度较快24 h时约有22%的药物被释放；NLC剂型体外释放速率次之，在24 h时约有17%的药物被释放；自由药物体外释放速率最慢，在24 h时只有5%的药物被释放。水凝胶有明显的药物缓释作用；另外，在一定范围内，摇床转速越高，药物的缓释效果更明显。结论：艾地苯醌纳米结构脂质载体的体外释放研究方法简单、快速，可以用于用以控制制剂质量，评价制剂工艺。%Objective To study on nanostructured lipid carriers system of idebenone to improve the bio-availability and prolong the circulation time in vivo meanwhile using dialysis bag diffusion method to investigate its release characteristics in vitro. Methods Through the study of different idebenone modes (nanostructured lipid carriers (NLC), nano emulsion (NE) and its hydrogel) in different environments (PH1.2, PH6.8, PH7.4) re-lease properties and different rotation speed variable conditions in vitro to simulate sustained release properties of lipid nanoparticles and hydrogel in the gastric juice, gut juice and humoral environment. Results Every drug loaded release characteristics of idebenone were different. NE release was faster, of which about 22% was released in 24 h. Free drug release was the slowest in 24 h in vitro, of which only 5% was released. Hydrogel had sustained effect obviously. In addition, the higher the rotational speed was, the more obvious the sustained release effected in a certain range. Conclusion Idebenone nanostructured lipid carriers in vitro release study method was simple and fast, and it can be used to control the quality of the preparation and evaluation of prepa-ration process.
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